Problem rifle

[Kurt]

I have a .45-90 Shiloh that has been a problem getting to shoot. For more then 12 years I been working with this rifle to shoot at least soft ball size groups (4") @ 200 yards reliably. This rifle is the cause of having a drawer full of custom made moulds and empty cases of powder. Goex, swiss, OE, Schuetzen and KIK in all granulations and a bunch of different primers as well as wads, PP or GG bullets. Compression from zero to hanging on the press handle. I even put a scope on this rifle.
Once in a while I will keep 5 shots in the 3" X ring but very seldom this happens. This rifle has three different barrels now.
Is there such a thing like the rifle just will not shoot????????
I'm at a loss with this rifle.

Kurt